Publications

2017

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017. 28(11):1467-1488

Etienne-Manneville S, Lammerding J. Connecting the plasma membrane to the nucleus by intermediate filaments. Mol Biol Cell. 2017. 15;28(6):695-696

Isermann P, Lammerding J. Consequences of a tight squeeze: Nuclear envelope rupture and repair. Nucleus. 2017. 8(3):1-7.

Shah P, Wolf K, Lammerding J. Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability? Trends Cell Biol. 2017. [Epub ahead of print]

2016

Kirby T, Lammerding J. Cell mechanotransduction: Stretch to express. Nature Materials. 2016(15):1227-9.

Lammerding J, Wolf K. Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus. J Cell Biol. 2016 Oct 10;215(1):5.

Cao X, Moeendarbary E, Isermann P, Davidson PM, Wang X, Chen MB, Burkart AK, Lammerding J, Kamm RD, Shenoy VB. A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration. Biophysical J. 2016 Oct 4;111(7):1541–52.

Luan JB, Shan HW, Isermann P, Huang JH, Lammerding J, Liu SS, Douglas AE. Cellular and molecular remodelling of a host cell for vertical transmission of bacterial symbiontsProc Biol Sci. 2016 Jun 29;283(1833).

Bell ES, Lammerding J. Causes and consequences of nuclear envelope alterations in tumour progressionEur J Cell Biol. 2016 Jun 25. Review.

Fedorchak G, Lammerding J. Cellular and molecular remodelling of a host cell for vertical transmission of bacterial symbiontsMethods Mol Biol. 2016;1411:241-54.

Denais CM, Gilbert RM, Isermann P, McGregor AL, te Lindert M, Weigelin B, Davidson PM, Friedl P, Wolf K, Lammerding J. Nuclear envelope rupture and repair during cancer cell migration. Science. 2016. 352(6283) 353-358.

McGregor AL, Hsia CR, Lammerding J. Squish and squeeze-the nucleus as a physical barrier during migration in confined environmentsCurr Opin Cell Biol. 2016. 16(40): 32-40. [Epub ahead of print]

2015

Shav-Tal Y, Lammerding J. Design (and) Principles of Nuclear Dynamics in Stockholm. Nucleus. 2015. 6(6): 425-9.

Davidson PM, Sliz J, Isermann P, Denais C, Lammerding J. Design of a microfluidic device to quantify intra-nuclear deformation during cell migration through confining environments. Integr Biol (Camb). 2015. 30(7): 1534-46.

Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR. Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. Am J Physiol Cell Physiol. 2015. 309(11): C736-46.

Zwerger M, Roschitzki-Voser H, Zbinden R, Denais C, Herrmann H, Lammerding J, Gruetter MG, and Medalia O. Altering lamina assembly identifies lamina-dependent and -independent functions for A-type lamins. J Cell Sci. 2015. 128(19): 3607-20.

Thomas DG, Yenepalli A, Denais CM, Rape A, Beach JR, Wang Y, Schiemann WP, Baskaran H, Lammerding J, Egelhoff TT. Non-muscle myosin IIB is critical for nuclear translocation during 3-D invasion. J Cell Biol. 2015. 210(4): 583-594.

Dialynas G, Shrestha OK, Ponce JM, Zwerger M, Thiemann DA, Young GH, Moore SA, Yu L, Lammerding J and Wallrath LL. Myopathic lamin mutations cause reductive stress and activate the Nrf2/Keap-1 pathway. PLoS Genetics. 2015. 11(5): e1005231. Published online May 21, 2015.

2014

Davidson P, Denais C, Bakshi M, Lammerding J. Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D EnvironmentsCell Mol BioEng J. 2014. Vol 7(3): 293-306

Kaminski A, Fedorchak GR, Lammerding J.  The cellular mastermind(?)-mechanotransduction and the nucleus. Prog Mol Biol Transl Sci. 2014;126:157-203.

Fedorchak GR, Kaminski A, Lammerding J. Cellular mechanosensing: Getting to the nucleus of it all. Prog Biophys Mol Biol. 2014 Jul 5. pii: S0079-6107(14)00051-0. doi: 10.1016/j.pbiomolbio.2014.06.009. [Epub]

Davidson PM, Lammerding J. Broken nuclei – lamins, nuclear mechanics, and disease. Trends Cell Biol. 2014 April 24 (4):247-256, Pages 247–256. 

Denais C, Lammerding J. Nuclear Mechanics in Cancer.  Advances in Experimental Medicine and Biology Cancer Biology, Volume 773; 2014 773:435-70.

2013

Isermann P, Lammerding J. Nuclear mechanics and mechanotransduction in health and disease. Curr Biol. 2013 Dec 16;23(24):R1113-21.  

Ho CY, Jaalouk DE, Lammerding J. Novel insights into the disease etiology of laminopathies. Rare Diseases. Published online 2013 Nov 6.

Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J. Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamicsNature 2013 May; 497(7450):507-11

Zwerger M, Jaalouk D, Lombardi M, Isermann P, Mauermann M, Dialynas G, Herrmann H, Wallrath L, Lammerding J. Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal couplingHum. Molecular Genetics 2013 Feb; (12):2335-49;

Rowat AC, Jaalouk DE, Zwerger M, Ung WL, Eydelnant IA, Olins D, Olins A, Herrmann H, Weitz DA, Lammerding J. Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions. J. Biol Chem. 2013 Jan; 288(12):8610-8. 

2012

Isermann P, Davidson PM, Sliz JD, Lammerding J. Assays to measure nuclear mechanics in interphase cells. Current Protoc Cell Biol. 2012; Chapter 22:Unit 22.16. 

Ho CY and Lammerding J. Lamins at a glance. J. Cell Sci. 2012; 125:2087-2093.

2011

Lombardi ML, Zwerger M, Lammerding J. Biophysical assays to probe the mechanical properties of the interphase cell nucleus: substrate strain and microneedle manipulation. JoVE. 2011; 14(55): pii:3087.

Verstraeten VLRM, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J. Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc Natl Acad Sci. 2011; 108(12): 4997-5002.

Lombardi ML, Jaalouk DE, Shanahan CM, Burke B, Roux KJ, Lammerding J. The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton. J Biol Chem. 2011; 286(30): 26743-53.

Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jan RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM. Cell surface sensors for real-time probing of cellular environmentsNature Nanotechnology. 2011; 6(8): 524-31.

Friedl P, Wolf K, Lammerding J. Nuclear mechanics during cell migration. Curr Opin Cell Biol. 2011; 3(1):55–64

Lombardi ML, Lammerding J. Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function. Biochem Soc Trans. 2011; 39(6):1729-1734.

Rich JP, Lammerding J, McKinley GH, Doyle PS. Nonlinear microrheology of an aging, yield stress fluid using magnetic tweezers. Soft Matter. 2011; 7: 9933-9943.

Lammerding J. Mechanics of the nucleus. In: Gerthoffer WT, Editor. Handbook of Physiology — Comprehensive Physiology. Wiley-Blackwell. 2011; 1:783-807.

Isermann P, Zwerger M, Lammerding J. Probing the biophysical properties of the cell nucleus and their relevance in health and disease. Cell News, Newsletter of the German Society for Cell Biology (DGZ). 2011; 24–29.

Zwerger M, Ho CY, Lammerding J. Nuclear mechanics in disease. Annu Rev Biomed Eng. 2011; 13:397-428.

2010

Verstraeten VLRM, Lammerding J. Another broken heart: Loss of lamina-associated polypeptide 2-alpha causes systolic dysfunction. Circ Res. 2010; 106(2): 234-237.

Cupesi M, Yoshioka J, Gannon J, Kudinova A, Stewart CL, Lammerding J. Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse. J Mol Cell Cardiol. 2010; 48(6): 1290-7.

Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. Direct synthesis of lamin A, bypassing prelamin A processing, causes mishapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010; 285(27): 20818-26.

Davies B, Barnes R, Tu Y, Ren S, Andrea DA, Spielmann HP, Lammerding J, Wang J, Young SG, Fong LG. An accumulation of nonfarnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Gen. 2010; 19(13): 2682-94.

Lombardi ML, Lammerding J. Mechanical properties of the nucleus in disease. In: Shivashankar GV, Editor. Methods in Cell Biology (Vol. 98) — Nuclear Mechanics and Genome Regulation. Amsterdam: Elsevier. 2010; 121-41.

2009

Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass DA, Lorenz JN, Robbins J.Biochemical and mechanical dysfunction in a mouse model of Desmin-related myopathy. Circ Res.2009; 104: 1021-1028.

Lammerding J, Lee RT. Mechanical properties of interphase nuclei probed by cellular strain application. In: Hancock R, Walker J, editors. The Nucleus (Methods in Molecular Biology). Springer. 2009; Vol. 464:13-26.

Jaalouk DE, Lammerding J. Mechanotransduction gone awry. Nature Rev Mol Cell Biol. 2009; 10(1): 63-73.

Huang H, MacGillivray C, Kwon HS, Lammerding J, Robbins, Lee RT, So PT. Three dimensional cardiac architecture determined by two-photon microtomy. J Biomed Optics. 2009; 14(4): 044029. 

Patwari P, Chutkow WA, Cummings K, Verstraeten LRM, Lammerding J, Schreiter ER, Lee RT.Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 2009; 284(37): 24996-25003.

2008

Dahl KN, Ribeiro AJS, Lammerding J. Nuclear shape, mechanics, and mechanotransduction. Circ Res. 2008; 102(11): 1307-1318.

Verstraeten VLRM, Lammerding J. Experimental techniques for study of chromatin mechanics in intact nuclei and living cells. Chromosome Res. 2008; vol 30: 226-236.

Verstraeten VLRM, Ji JY, Cummings KS, Lee RT, Lammerding J. Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. Aging Cell. 2008; 7(3):383-93.

Rowat AC, Lammerding J, Herrmann H, Aebi U. Towards an intergrated understanding of the structure and mechanics of the cell nucleus. BioEssays. 2008; vol 30: 226-236.

2007

Lammerding J, Dahl KN, Discher DE, Kamm RD. Nuclear mechanics and methods. In: Wang YL, Discher DE, editors. Methods in Cell Biology. (Vol 83) — Cell Mechanics. Amsterdam: Elsevier. 2007; 269-294.

Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J. Cell nuclei spin in the absence of lamin B1. J Biol Chem. 2007; 282(27): 20015-20026.

Lammerding J, Lee RT. Torn apart–Membrane rupture in muscular dystrophies and associated cardiomyopathies. Invited commentary. J Clin Invest. 2007; 177(7): 1749-52.

2006

Rowat AC, Lammerding J, Ipsen JH. Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys J. 2006; 91(12): 4649-4664.

Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. Lamin A and lamin C but not lamin B regulate nuclear mechanics. J Biol Chem. 2006; 281(35): 25768-25780.

Fong L, Ng JK, Lammerding J, Vickers TA, Meta M, Cote N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennet CF, Bergo MO, Young SG. Prelamin A and lamin A appear to be dispensable–implications for progeria. J Clin Invest. 2006; 116(3): 743-752.

2005

Hakuno D, Takahashi T, Lammerding J, Lee RT. Focal adhesion kinase signaling regulated cardiogenesis of embryonic stem cells. J Biol Chem. 2005; 280(47): 39534-39544.

Lammerding J, Hsiao J, Schulze PC, Kozlov S, Stewart CL, Lee RT. Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol. 2005; 170(5): 781-791.

Lammerding J, Lee RT. The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C deficient cells. In: Novartis Found Symp. 2005; 264:264–73; discussion 273–8.

2004

Lammerding J, Schulze PC, Takahashi T, Kozlov S, Sullivan T, Kamm RD, Stewart CL, Lee RT. Lamin A/C deficiency causes defective nuclear mechanics ad mechanotransduction. J Clin Invest. 2004 Feb; 113(3): 370-378.

Lammerding J, Kamm, RD, Lee RT. Mechanotransduction in cardiac myocytes. Ann N Y Acad. Sci. 2004; 1015:53–70.

2003

Lammerding J, Huang H, So PT, Kamm RD, Lee RT. Quantitative measurements of active and passive mechanical properties of adult cardiac mycytes. IEEE Eng Med Biol Mag. 2003 Sep/Oct; 22(5): 124-127.

Karcher H, Lammerding J, Huang H, Lee RT, Kamm RD, Kaazempur-Mofrad MR. A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophys J. 2003 Nov; 85(5): 3336-3349.

Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME. Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc Natl Acad Sci. 2003 Jun; 100(13): 7616-7621.

2002

Lammerding J, Huang H, So PT, Kamm RD, Lee RT. Quantitative measurements of active and passive mechanical properties of adult cardiac myocytes. Conference Proceedings. Second Joint IEEE EMBS/BMES Conference 2002. 24th Annual Conference of the Engineering in Medicine and Biology Society. Annual Meeting of the Biomedical Engineering Society.  2002; p5. 1, p. 298-9, vol 1.

Lee, R.T., Lammerding, J. Signaling pathways that influence extracellular remodeling. J Card Fail. 2002; 8(6 Suppl):S339–43.

1999

Pandorf T, Haddi A, Wirtz DC, Lammerding J, Forst R, Wechert D. Numerical simulation of adaptive bone remodeling. J Theor Appl Mech. 1999; 37(3): 639-658.
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