2025
Amiad Pavlov D*, Heffler J*, Suay-Corredera C, Dehghany M, Shen KM, Zuela-Sopilniak N, Randell R, Uchida K, Jain R, Shenoy V, Lammerding J, Prosser B. Microtubule forces drive nuclear damage in LMNA cardiomyopathy. Nat Cardiovasc Res. Published online on 10/10/2025. [Publisher’s site]
Heffler J, Lammerding J. FOMO no more: NOMO and calmin extend mechanobiology to the ER. J Cell Biol. 2025;224(9):e202508037. [Publisher’s site | PubMed]
Henretta S, Lammerding J. Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression. NPJ Biol Phys Mech. 2025;2(1):14. [Publisher’s site | PubMed Central]
Bragantini J, Theodoro I, Zhao X, Huijben TAPM, Hirata-Miyasaki E, VijayKumar S, Balasubramanian A, Lao T, Agrawal R, Xiao S, Lammerding J, Mehta S, Falcão AX, Jacobo A, Lange M, & Royer, LA. Ultrack: pushing the limits of cell tracking across biological scales. Nat Methods. Published online August 25, 2025. [Publisher’s site | PubMed]
Henretta S*, Bockley K*, Odell J, Lammerding J. Filamin A interacting protein 1-like (FILIP1L) has mitochondrial localization. microPublication Biology. Published online on 3/25/2025. [Publisher’s site | PubMed Central]
Morival J*, Hazelwood A*, Lammerding J. Feeling the force from within: new tools and insights into nuclear mechanotransduction. J Cell Sci. 2025: 138(5):JCS263615. [Publisher’s site | PubMed Central]
* authors contributed equally
2024
Yang C, Leifer C, Lammerding J, Hu F. Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation. J Biol Chem. 2024. 300(12): 107999 [Publisher’s site | PubMed Central]
Odell J, Lammerding J. N-terminal tags impair the ability of Lamin A to provide structural support to the nucleus. J Cell Sci. 2024. 137 (16): jcs262207. [Publisher’s site | PubMed Central]
Keys J, Cheung BCH, Elpers MA, Wu M, Lammerding J. Rear cortex contraction aids in nuclear transit during confined migration by increasing pressure in the cell posterior. J Cell Sci. 2024. 137 (12): jcs260623 [Publisher’s site | PubMed Central]
Kirby TJ, Zahr HC, Fong EHH, Lammerding J. Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A/C-deficient mice. Cell Death Discovery. 2024. 10(1):245 [Publisher’s site | PubMed Central]
[Publisher’s site | PubMed Central]
Odell J, Gräf R, Lammerding J. Heterologous expression of Dictyostelium discoideum NE81 in mouse embryo fibroblasts reveals conserved mechanoprotective roles of lamins. Mol Biol Cell. 2024 Jan 1;35(1):ar7 [Publisher’s site | PubMed Central]
2023
Tan ML, Jenkins-Johnston N, Huang S, Schutrum B, Vadhin S, Adhikari A, Williams RM, Zipfel WR, Lammerding J, Varner JD, Fischbach C. Endothelial cells metabolically regulate breast cancer invasion towards microvessels. APL Bioengineering. 2023. 7(4): 046116
[Publisher’s site | PubMed Central]
Odell J, Lammerding J. Lamins as structural nuclear elements through evolution. Curr Opin Cell Biol. 85: 102267 [Publisher’s site | PubMed Central]
Smolka MB, Lammerding J. ATR takes a crack at the nuclear envelope. 2023. Mol Cell. 83(20): 3588-3590 [Publisher’s site | PubMed]
[Publisher’s site | PubMed Central]
Elpers MA, Varlet AA, Agrawal R, Lammerding J. Agarose-based 3D cell confinement assay to study nuclear mechanobiology. Current Protocols. 2023. 3(7):e847 [Publisher’s site | PubMed Central]
Aakula A, Isormursu A, Rupp C, Erickson A, Gupta N, Kauko O, Shah P, Padzik A, Pokharel YR, Kaur A, Li SP, Trotman L, Taimen P, Ranniko A, Lammerding J, Paatero I, Mirtti T, Ivaska J, Westermarck J. PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers. Mol Oncology. 2023. 17(6): 1007-1023 [Publisher’s site | PubMed Central]
Wallace M, Fedorchak GR, Agrawal R, Gilbert RM, Patel J, Park S, Paszek M, Lammerding J. The Lamin A/C Ig-fold undergoes cell density-dependent changes that altered epitope binding. Nucleus. 2023. 14(1):2180206 [Publisher’s site | PubMed Central]
2022
Lammerding J, Engler AJ, Kamm R. Mechanobiology of the cell nucleus. APL Bioeng. 2022. 6(4): 040401 [Publisher’s site | PubMed Central]
Mehl J, Earle A, Lammerding J, Mhlanga M, Vogel V, Jain N. Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response. iScience. 2022. 25(12):105528 [Publisher’s site | PubMed Central]
Sanketi BD, Zuela-Sopilniak N, Bundschuh E, Gopal S, Hu S, Long J, Lammerding J, Hopyan S, Kurpios NA. Pitx2 patterns an accelerator-brake mechanical feedback through latent TGFβ to rotate the gut. Science. 2022. 377(6613):eabl3921. [Publisher’s site | PubMed Central]
Shaw N, Rios-Monterrosa J, Fedorchak G, Ketterer M, Coombs G, Lammerding J, Wallrath L. Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy. Frontiers Cell Dev Biol. 2022. 10: 934586 [Publisher’s site | PubMed Central]
Hsia C-R, McAllister J, Hasan O, Judd J, Lee S, Agrawal R, Chang C-Y, Soloway P, Lammerding J. Confined migration induces heterochromatin formation and alters chromatin accessibility. iScience. 2022. 25(9):104978 [Publisher’s site | PubMed Central]
Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival LP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, Lakins JN, Vahdat L, Weaver WM, Smolka MB, Span PN, Lammerding J. Oncogene. (2022). Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer. 2022. 41(36): 4211-4230 [Publisher’s site | PubMed Central]
Zuela-Sopilniak N, Lammerding J. Can’t handle the stress? Mechanobiology and disease. Trends in Molecular Medicine. 2022. 28(9): 710-725 [Publisher’s site | PubMed Central]
Shah P, McGuigan CW, Cheng S, Vanpouille-Box C, Demaria S, Weiss RS, Lammerding J. ATM modulates nuclear mechanics by regulating lamin A levels. Frontiers Cell Dev Biol. 2022. 10: 875132 [Publisher’s site | PubMed Central]
Kalukala Y, Stephens AD, Lammerding J, Gabriele S. Mechanics and functional consequences of nuclear deformations. Nature Reviews Mol Cell Biol. 2022. [Publisher’s site | PubMed Central]
Agrawal R, Windsor A, Lammerding J. Assembly and use of a microfluidic device to study nuclear mechanobiology during confined migration. Methods Mol Biol. 2022. 2502: 329-349 [Publisher’s site | PubMed Central]
Tollis S, Rizzotto A, Pham NT, Koivukoski S, Sivakumar A, Shave S, Wildenhain J, Zuleger N, Keys JT, Culley J, Zheng Y, Lammerding J, Carragher NO, Brunton VG, Latonen L, Auer M, Tyers M, Schirmer EC. Chemical interrogation of nuclear size identifies compounds with cancer cell line-specific effects on migration and invasion. ACS Chemical Biology. 2022. 17(3): 680-700 [Publisher’s site | PubMed Central]
Huth S, Blumber JW, Probst D, Lammerding J, Schwarz US, Selhuber-Unkel C. Quantifying force transmission through fibroblasts: changes of traction forces under external shearing. European Biophysics Journal. 2022. 51(2): 157-169 [Publisher’s site | PubMed Central]
2021
Wang H, Alarcon CN, Liu B, Watson F, Searles S, Lee CK, Keys J, Pi W, Allen D, Lammerding J, Bui J, Klemke RL. Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue. Published online Dec 20, 2021 [Publisher’s site | PubMed Central]
Shah P, Hobson CM, Cheng S, Colville MJ, Paszek MJ, Superfine R, Lammerding, J. Nuclear Deformation Causes DNA Damage by Increasing Replication Stress. Current Biology. 2021. 31(4): 753-765 [Publisher’s site | PubMed Central]
Siemsen K, Rajput S, Rasch F, Taheri F, Adelung R, Lammerding J, Selhuber-Unkel C. Tunable three-dimensional hydrogel microchannel networks to study confined mammalian cell migration. Advanced Healthcare Materials. 2021. 10(23): e2100625 [Publisher’s site | PubMed Central]
2020
Lammerding J, Hsia CR. Feeling stressed? Piezo1-mediated loss of heterochromatin buys time for long-term adaptation. Cell. 2020. 181(4):760-762 [Publisher’s site | PubMed]
Earle, A.J., Kirby, T.J., Fedorchak, G.R., Isermann, P., Patel, J., Iruvanti, S., Moore, S.A., Bonne, G., Wallrath, L.L., Lammerding, J. Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells. Nature Materials. 2020. 19(4): 464-473 [Publisher’s site | PubMed Central]
Liu, A., Yu, T., Young, K., Stone, N., Hanasoge S., Kirby, T.J., Varadarajan, V., Colonna, N., Liu, J., Raj, A., Lammerding, J., Alexeev, A., Sulchek, T. Cell Mechanical and Physiological Behavior in the Regime of Rapid Mechanical Compressions that Lead to Cell Volume Change. Small. 2020. 16(2): e1903857. [Publisher’s site | PubMed Central]
2019
Mistriotis, P., Wisniewski, E.O., Bera, K., Keys, J., Li, Y., Tuntithavornwat, S., (et al.) Lammerding, J., Konstantopoulos, K. Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing. Journal of Cell Biology. 2019. 218 (12): pp. 4093-4111.
[Publisher’s site | PubMed Central]
He, F., Springer, N.L., Whitman, M.A., Pathi, S.P., Lee, Y., Mohanan, S., Marcott, S., Chiou, A.E., Blank, B.S., Iyengar, N., Morris, P.G., Jochelson, M., Hudis, C.A., Shah, P., Kunitake, J.A.M.R., Estroff, L.A., Lammerding, J., Fischbach, C. Hydroxyapatite mineral enhances malignant potential in a tissue-engineered model of ductal carcinoma in situ (DCIS). Biomaterials. 224:Article 119489. 2019 [Publisher’s site | PubMed Central]
Davidson, P.M., Fedorchak, G.R., Mondésert-Deveraux, S., Bell, E.S., Isermann, P., Aubry, D., Allena, R., Lammerding, J., High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells. Lab on a chip. 2019. 21: 3652-3663. [Publisher’s site | PubMed Central]
Zuela-Sopilniak N, Lammerding J. Engineering approaches to studying cancer cell migration in three-dimensional environments. Philosophical Transactions of the Royal Society B: Biological Sciences. 2019. 374(1779). [Publisher’s site | PubMed Central]
Krause M, Yang FW, Te Lindert M, Isermann P, Schepens J, Maas RJA, Venkataraman C, Lammerding J, Madzvamuse A, Hendriks W, Te Riet J, Wolf K. <Cell migration through three-dimensional confining pores: Speed accelerations by deformation and recoil of the nucleus. Philosophical Transactions of the Royal Society B: Biological Sciences. 2019. 374(1779). [Publisher’s site | PubMed Central]
Maurer M, Lammerding J. The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease. Annual Rev of Biomedical Engingeering. 2019. 21: pp. 443-468. [Publisher’s site | PubMed Central]
Zhang Q, Tamashunas A, Agrawal A, Torbati M, Katiyar A, Dickinson RB, Lammerding J, Lele TP. Local, transient tensile stress on the nuclear membrane causes membrane rupture. Mol Biol Cell. 2019. 30(7): 899-906. [Publisher’s site | PubMed Central]
2018
Kirby, T.J., Lammerding, J. Emerging views of the nucleus as a cellular mechanosensor. Nature Cell Biology. 2018. 20(4), pp. 373-381
[Publisher’s site | PubMed Central]
Keys J, Windsor A, Lammerding J. Assembly and use of a microfluidic device to study cell migration in confined environments. Methods Mol Biol. 2018. 1840:101-118 [Publisher’s site | PubMed]
Elacqua JJ, McGregor AL, Lammerding J. Automated analysis of cell migration and nuclear envelope rupture in confined environments. PLoS ONE. 2018. 13(4),e0195664 [Publisher’s site | PubMed Central]
Singh A, Brito I, Lammerding J. Beyond Tissue Stiffness and Bioadhesivity: Advanced Biomaterials to Model Tumor Microenvironments and Drug Resistance. Trends in Cancer. 2018. 4(4), pp. 281-291 [Publisher’s site | PubMed Central]
Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018. 553(7689), pp. 467-472 [Publisher’s site | PubMed Central]
Yadav SK, Feigelson SW, Roncato F, Antman-Passig M, Shefi O, Lammerding J, Alon R. Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers. Journal of Leukocyte Biology. 2018. 104(2): 239–251
[Publisher’s site | PubMed Central]
2017
Morelli FF, Verbeek DS, Bertacchini J, Vinet J, Mediani L, Marmiroli S, Cenacchi G, Nasi M, De Biasi S, Brunsting JF, Lammerding J, Pegoraro E, Angelini C, Tupler R, Alberti S, Carra S. Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function. Cell Reports. 2017. 20(9), pp. 2100-2115 [Publisher’s site | PubMed Central]
Shah P, Wolf K, Lammerding J. Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability?. Trends in Cell Biology. 2017. 27(8), pp. 546-555 [Publisher’s site | PubMed Central]
Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017. 28(11):1467-1488 [Publisher’s site | PubMed Central]
Etienne-Manneville S, Lammerding J. Connecting the plasma membrane to the nucleus by intermediate filaments. Mol Biol Cell. 2017. 15;28(6):695-696 [Publisher’s site | PubMed Central]
Isermann P, Lammerding J. Consequences of a tight squeeze: Nuclear envelope rupture and repair. Nucleus. 2017. 8(3):1-7. [Publisher’s site | PubMed Central]
2016
Kirby T, Lammerding J. Cell mechanotransduction: Stretch to express. Nature Materials. 2016(15):1227-9. [Publisher’s site | PubMed]
Lammerding J, Wolf K. Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus. J Cell Biol. 2016 Oct 10;215(1):5. [Publisher’s site | PubMed Central]
Cao X, Moeendarbary E, Isermann P, Davidson PM, Wang X, Chen MB, Burkart AK, Lammerding J, Kamm RD, Shenoy VB. A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration. Biophysical J. 2016 Oct 4;111(7):1541–52.
[Publisher’s site | PubMed Central]
Luan JB, Shan HW, Isermann P, Huang JH, Lammerding J, Liu SS, Douglas AE. Cellular and molecular remodelling of a host cell for vertical transmission of bacterial symbionts. Proc Biol Sci. 2016 Jun 29;283(1833). [Publisher’s site | PubMed Central]
Bell ES, Lammerding J. Causes and consequences of nuclear envelope alterations in tumour progression. Eur J Cell Biol. 2016 Jun 25. Review. [Publisher’s site | PubMed Central]
Fedorchak G, Lammerding J. Cellular and molecular remodelling of a host cell for vertical transmission of bacterial symbionts. Methods Mol Biol. 2016;1411:241-54. [Publisher’s site | PubMed Central]
Denais CM, Gilbert RM, Isermann P, McGregor AL, te Lindert M, Weigelin B, Davidson PM, Friedl P, Wolf K, Lammerding J. Nuclear envelope rupture and repair during cancer cell migration. Science. 2016. 352(6283) 353-358. [Publisher’s site | PubMed Central]
McGregor AL, Hsia CR, Lammerding J. Squish and squeeze-the nucleus as a physical barrier during migration in confined environments. Curr Opin Cell Biol. 2016. 16(40): 32-40. [Epub ahead of print] [Publisher’s site | PubMed Central]
2015
Shav-Tal Y, Lammerding J. Design (and) Principles of Nuclear Dynamics in Stockholm. Nucleus. 2015. 6(6): 425-9. [Publisher’s site | PubMed Central]
Davidson PM, Sliz J, Isermann P, Denais C, Lammerding J. Design of a microfluidic device to quantify intra-nuclear deformation during cell migration through confining environments. Integr Biol (Camb). 2015. 30(7): 1534-46. [Publisher’s site | PubMed Central]
Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR. Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. Am J Physiol Cell Physiol. 2015. 309(11): C736-46. [Publisher’s site | PubMed Central]
Zwerger M, Roschitzki-Voser H, Zbinden R, Denais C, Herrmann H, Lammerding J, Gruetter MG, and Medalia O. Altering lamina assembly identifies lamina-dependent and -independent functions for A-type lamins. J Cell Sci. 2015. 128(19): 3607-20. [Publisher’s site | PubMed Central]
Thomas DG, Yenepalli A, Denais CM, Rape A, Beach JR, Wang Y, Schiemann WP, Baskaran H, Lammerding J, Egelhoff TT. Non-muscle myosin IIB is critical for nuclear translocation during 3-D invasion. J Cell Biol. 2015. 210(4): 583-594. [Publisher’s site | PubMed Central]
Dialynas G, Shrestha OK, Ponce JM, Zwerger M, Thiemann DA, Young GH, Moore SA, Yu L, Lammerding J and Wallrath LL. Myopathic lamin mutations cause reductive stress and activate the Nrf2/Keap-1 pathway. PLoS Genetics. 2015. 11(5): e1005231. Published online May 21, 2015. [Publisher’s site | PubMed Central]
2014
Davidson P, Denais C, Bakshi M, Lammerding J. Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments. Cell Mol BioEng J. 2014. Vol 7(3): 293-306 [Publisher’s site | PubMed Central]
Kaminski A, Fedorchak GR, Lammerding J. The cellular mastermind(?)-mechanotransduction and the nucleus. Prog Mol Biol Transl Sci. 2014;126:157-203. [Publisher’s site | PubMed Central]
Fedorchak GR, Kaminski A, Lammerding J. Cellular mechanosensing: Getting to the nucleus of it all. Prog Biophys Mol Biol. 2014 Jul 5. pii: S0079-6107(14)00051-0. doi: 10.1016/j.pbiomolbio.2014.06.009. [Epub] [Publisher’s site | PubMed Central]
Davidson PM, Lammerding J. Broken nuclei – lamins, nuclear mechanics, and disease. Trends Cell Biol. 2014 April 24 (4):247-256, Pages 247–256. [Publisher’s site | PubMed Central]
Denais C, Lammerding J. Nuclear Mechanics in Cancer. Advances in Experimental Medicine and Biology Cancer Biology, Volume 773; 2014 773:435-70. [Publisher’s site | PubMed Central]
2013
Isermann P, Lammerding J. Nuclear mechanics and mechanotransduction in health and disease. Curr Biol. 2013 Dec 16;23(24):R1113-21. [Publisher’s site | PubMed Central]
Ho CY, Jaalouk DE, Lammerding J. Novel insights into the disease etiology of laminopathies. Rare Diseases. Published online 2013 Nov 6. [Publisher’s site | PubMed Central]
Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J. Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature 2013 May; 497(7450):507-11 [Publisher’s site | PubMed Central]
Zwerger M, Jaalouk D, Lombardi M, Isermann P, Mauermann M, Dialynas G, Herrmann H, Wallrath L, Lammerding J. Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling. Hum. Molecular Genetics 2013 Feb; (12):2335-49; [Publisher’s site | PubMed Central]
Rowat AC, Jaalouk DE, Zwerger M, Ung WL, Eydelnant IA, Olins D, Olins A, Herrmann H, Weitz DA, Lammerding J. Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions. J. Biol Chem. 2013 Jan; 288(12):8610-8. [Publisher’s site | PubMed Central]
2012
Lombardi ML, Zwerger M, Lammerding J. Biophysical assays to probe the mechanical properties of the interphase cell nucleus: substrate strain and microneedle manipulation. JoVE. 2011; 14(55): pii:3087. [Publisher’s site | PubMed Central]
Verstraeten VLRM, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J. Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc Natl Acad Sci. 2011; 108(12): 4997-5002. [Publisher’s site | PubMed Central]
Lombardi ML, Jaalouk DE, Shanahan CM, Burke B, Roux KJ, Lammerding J. The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton. J Biol Chem. 2011; 286(30): 26743-53. [Publisher’s site | PubMed Central]
Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jan RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM. Cell surface sensors for real-time probing of cellular environments. Nature Nanotechnology. 2011; 6(8): 524-31. [Publisher’s site | PubMed Central]
Friedl P, Wolf K, Lammerding J. Nuclear mechanics during cell migration. Curr Opin Cell Biol. 2011; 3(1):55–64 [Publisher’s site | PubMed Central]
Lombardi ML, Lammerding J. Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function. Biochem Soc Trans. 2011; 39(6):1729-1734. [Publisher’s site | PubMed Central]
Rich JP, Lammerding J, McKinley GH, Doyle PS. Nonlinear microrheology of an aging, yield stress fluid using magnetic tweezers. Soft Matter. 2011; 7: 9933-9943. [Publisher’s site]
Lammerding J. Mechanics of the nucleus. In: Gerthoffer WT, Editor. Handbook of Physiology — Comprehensive Physiology. Wiley-Blackwell. 2011; 1:783-807. [Publisher’s site]
Isermann P, Zwerger M, Lammerding J. Probing the biophysical properties of the cell nucleus and their relevance in health and disease. Cell News, Newsletter of the German Society for Cell Biology (DGZ). 2011; 24–29.
Zwerger M, Ho CY, Lammerding J. Nuclear mechanics in disease. Annu Rev Biomed Eng. 2011; 13:397-428. [Publisher’s site | PubMed Central]
2010
Verstraeten VLRM, Lammerding J. Another broken heart: Loss of lamina-associated polypeptide 2-alpha causes systolic dysfunction. Circ Res. 2010; 106(2): 234-237. [Publisher’s site | PubMed Central]
Cupesi M, Yoshioka J, Gannon J, Kudinova A, Stewart CL, Lammerding J. Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse. J Mol Cell Cardiol. 2010; 48(6): 1290-7. [Publisher’s site | PubMed Central]
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. Direct synthesis of lamin A, bypassing prelamin A processing, causes mishapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010; 285(27): 20818-26. [Publisher’s site | PubMed Central]
Davies B, Barnes R, Tu Y, Ren S, Andrea DA, Spielmann HP, Lammerding J, Wang J, Young SG, Fong LG. An accumulation of nonfarnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Gen. 2010; 19(13): 2682-94. [Publisher’s site | PubMed Central]
Lombardi ML, Lammerding J. Mechanical properties of the nucleus in disease. In: Shivashankar GV, Editor. Methods in Cell Biology (Vol. 98) — Nuclear Mechanics and Genome Regulation. Amsterdam: Elsevier. 2010; 121-41. [Publisher’s site | PubMed]
2009
Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass DA, Lorenz JN, Robbins J.Biochemical and mechanical dysfunction in a mouse model of Desmin-related myopathy. Circ Res.2009; 104: 1021-1028. [Publisher’s site | PubMed Central]
Lammerding J, Lee RT. Mechanical properties of interphase nuclei probed by cellular strain application. In: Hancock R, Walker J, editors. The Nucleus (Methods in Molecular Biology). Springer. 2009; Vol. 464:13-26. [Publisher’s site | PubMed Central]
Jaalouk DE, Lammerding J. Mechanotransduction gone awry. Nature Rev Mol Cell Biol. 2009; 10(1): 63-73. [Publisher’s site | PubMed Central]
Huang H, MacGillivray C, Kwon HS, Lammerding J, Robbins, Lee RT, So PT. Three dimensional cardiac architecture determined by two-photon microtomy. J Biomed Optics. 2009; 14(4): 044029. [Publisher’s site | PubMed Central]
Patwari P, Chutkow WA, Cummings K, Verstraeten LRM, Lammerding J, Schreiter ER, Lee RT.Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 2009; 284(37): 24996-25003. [Publisher’s site | PubMed Central]
2008
Dahl KN, Ribeiro AJS, Lammerding J. Nuclear shape, mechanics, and mechanotransduction. Circ Res. 2008; 102(11): 1307-1318. [Publisher’s site | PubMed Central]
Verstraeten VLRM, Lammerding J. Experimental techniques for study of chromatin mechanics in intact nuclei and living cells. Chromosome Res. 2008; vol 30: 226-236. [Publisher’s site | PubMed]
Verstraeten VLRM, Ji JY, Cummings KS, Lee RT, Lammerding J. Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. Aging Cell. 2008; 7(3):383-93. [Publisher’s site | PubMed Central]
Rowat AC, Lammerding J, Herrmann H, Aebi U. Towards an intergrated understanding of the structure and mechanics of the cell nucleus. BioEssays. 2008; vol 30: 226-236. [Publisher’s site | PubMed]
2007
Lammerding J, Dahl KN, Discher DE, Kamm RD. Nuclear mechanics and methods. In: Wang YL, Discher DE, editors. Methods in Cell Biology. (Vol 83) — Cell Mechanics. Amsterdam: Elsevier. 2007; 269-294. [Publisher’s site | PubMed]
Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J. Cell nuclei spin in the absence of lamin B1. J Biol Chem. 2007; 282(27): 20015-20026. [Publisher’s site | PubMed]
Lammerding J, Lee RT. Torn apart–Membrane rupture in muscular dystrophies and associated cardiomyopathies. Invited commentary. J Clin Invest. 2007; 177(7): 1749-52. [Publisher’s site | PubMed Central]
2006
Rowat AC, Lammerding J, Ipsen JH. Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys J. 2006; 91(12): 4649-4664. [Publisher’s site | PubMed Central]
Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. Lamin A and lamin C but not lamin B regulate nuclear mechanics. J Biol Chem. 2006; 281(35): 25768-25780. [Publisher’s site | PubMed]
Fong L, Ng JK, Lammerding J, Vickers TA, Meta M, Cote N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennet CF, Bergo MO, Young SG. Prelamin A and lamin A appear to be dispensable–implications for progeria. J Clin Invest. 2006; 116(3): 743-752. [Publisher’s site | PubMed Central]
2005
Hakuno D, Takahashi T, Lammerding J, Lee RT. Focal adhesion kinase signaling regulated cardiogenesis of embryonic stem cells. J Biol Chem. 2005; 280(47): 39534-39544. [Publisher’s site | PubMed]
Lammerding J, Hsiao J, Schulze PC, Kozlov S, Stewart CL, Lee RT. Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol. 2005; 170(5): 781-791. [Publisher’s site | PubMed Central]
Lammerding J, Lee RT. The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C deficient cells. In: Novartis Found Symp. 2005; 264:264–73; discussion 273–8. [PubMed]
2004
Lammerding J, Schulze PC, Takahashi T, Kozlov S, Sullivan T, Kamm RD, Stewart CL, Lee RT. Lamin A/C deficiency causes defective nuclear mechanics ad mechanotransduction. J Clin Invest. 2004 Feb; 113(3): 370-378. [Publisher’s site | PubMed Central]
Lammerding J, Kamm, RD, Lee RT. Mechanotransduction in cardiac myocytes. Ann N Y Acad. Sci. 2004; 1015:53–70. [Publisher’s site | PubMed]
2003
Lammerding J, Huang H, So PT, Kamm RD, Lee RT. Quantitative measurements of active and passive mechanical properties of adult cardiac mycytes. IEEE Eng Med Biol Mag. 2003 Sep/Oct; 22(5): 124-127. [Publisher’s site | PubMed]
Karcher H, Lammerding J, Huang H, Lee RT, Kamm RD, Kaazempur-Mofrad MR. A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophys J. 2003 Nov; 85(5): 3336-3349. [Publisher’s site | PubMed Central]
Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME. Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc Natl Acad Sci. 2003 Jun; 100(13): 7616-7621. [Publisher’s site | PubMed Central]
2002
Lammerding J, Huang H, So PT, Kamm RD, Lee RT. Quantitative measurements of active and passive mechanical properties of adult cardiac myocytes. Conference Proceedings. Second Joint IEEE EMBS/BMES Conference 2002. 24th Annual Conference of the Engineering in Medicine and Biology Society. Annual Meeting of the Biomedical Engineering Society. 2002; p5. 1, p. 298-9, vol 1. [Publisher’s site]
Lee, R.T., Lammerding, J. Signaling pathways that influence extracellular remodeling. J Card Fail. 2002; 8(6 Suppl):S339–43. [Publisher’s site | PubMed]
1999
Pandorf T, Haddi A, Wirtz DC, Lammerding J, Forst R, Wechert D. Numerical simulation of adaptive bone remodeling. J Theor Appl Mech. 1999; 37(3): 639-658. [PDF]
